Title: AN UPDATED REVIEW ON SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS)
Author(s): Abhijeet Ojha, Mini Ojha & N.V. Satheesh Madhav
The oral route is the most common administration route for majority of drugs. But more than 40% of drugs exhibit poor aqueous solubility, resulting in low bioavailability, high intra and inter‐subject variability, and a lack of dose proportionality by oral route. To improve the oral bioavailability of lipophilic drugs, self‐emulsifying drug delivery systems (SEDDS) have emerged. SEDDS are isotropic mixtures of oil, surfactants, solvents and co‐solvents.The principal characteristic of these systems is their ability to form fine oil‐in‐water (o/w) emulsions or micro emulsions upon mild agitation following dilution by an aqueous phase through the gastrointestinal tract for lipophilic drugs. SEDDS may be a promising strategy to improve the rate and extent of oral absorption. This article gives an overview of various formulation strategies, characterization and applications of SEDDS.
Keywords: Self emulsifying drug delivery systems (SEDDS), Hydrophobic drugs, Bioavailability enhancement, Lipid based drug delivery system, Surfactants.