SCREENING OF ZIZIPHUS JUJUBE LAM. LEAF EXTRACT FOR ANTIMICROBIAL ACTIVITY

Title: SCREENING OF ZIZIPHUS JUJUBE LAM. LEAF EXTRACT FOR ANTIMICROBIAL ACTIVITY

Author(s): Senthamarai R, Ismail A M, Shri Vijaya Kirubha T and Balasubramanian P

ABSTRACT

Many medicinal plants are considered to be potential anti microbial crude drugs as well as a source for novel compounds with anti microbial activity with possibly new modes of action. The development of anti microbial compounds from natural sources is considered to be a promising approach. The present work was aimed to screen a selected plant for (novel) anti microbial compounds. Leaves of Ziziphus jujube (Rhamnaceae) – one of the 40 species of the genus Ziziphus have been reported to possess anti microbial properties. The coarsely powdered leaves were subjected to Soxhlet extraction using organic solvents of increasing polarity. The extracts were subjected to preliminary phytochemical screening and the ethanolic extract showed the presence of more phytoconstituents including flavanoids. Thence, ethanolic extract was subjected to anti microbial screening which showed significant anti bacterial activity against gram positive bacteria – Bacillius subtilis, Staphylococcus aureus & gram negative bacteria –    Escherichia coli, Klebsiella pneumonia as compared to standard drug – ciprofloxacin and anti fungal activity against Candida albicans, Aspergillus niger as compared to standard drug nystatin. The anti microbial activity exhibited by the selected plant – Ziziphus jujube may be due to the presence of flavanoids which possesses significant anti microbial activity. Thereby, it may be concluded that Ziziphus jujube leaves may be a drug of choice as good natural anti microbial agent.

Keywords: Ziziphus jujube, Flavanoids, Anti microbial activity

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