PROTECTIVE EFFECT OF MALUS PUMILA ON E. COLI INDUCED PERITONITIS IN ALBINO WISTAR RATS AND ITS ANTIOXIDANT ACTIVITIES

Title: A CASE STUDY ON LABOUR WELFARE SCHEME AT EMAMI PAPER MILL PVT. LTD IN BALASORE DISTRICT, ODISHA

Author(s): A. Nayak, R. Rusiya and M.A. Khan

ABSTRACT

Infectious or non-infectious peritonitis leads to systemic inflammation due to violation of the peritoneum which is often fatal. Evidences suggest that apple peel has a wide range of polyphenols having antioxidant activity and its consumption has been linked with improved health benefits. The aim of the present investigation was evaluate the in vitro antimicrobial, in vitro, in vivo antioxidant and protective potential of the methanolic and aqueous extract of M. pumila in E. coli induced model of peritonitis in albino wistar rats. Rats were pre-treated with 200 mg/kg and 400 mg/kg/bwt dose for 3 days and fourth day with E. coli (1×108 CFU/ml) strain and consecutively 3 days treatment. Mortality was monitored for 14 days. After the death of rats or completion of the experiment rats were sacrifice and kidney were used for our protocol. Colonies were count and statically analysis was done. Results showed dose dependent anti-microbial activity. Thus the aqueous extract of M. pumila exhibited significant protection against E. coli induced peritonitis in normal rats. It significantly reduced the viable cells of E. coli when inoculated in rats. Activity is attributed to flavonoids and polyphenols. The present study thus suggests that aqueous extract of M. pumila significantly reverses peritoneal infection by E. coli in rats. It can be suggest that this medicinal formulation will be used as herbal medicine with no side effects. The high content of phenolic compounds, antioxidant activity, and antimicrobial activity of apple peels indicate that they may impart health benefits when consumed and should be regarded as a valuable source of antioxidants. Thus, consumption of apple fruits along with peel might be recommended to gaining better nutritive benefits.

KEYWORDS: M. pumila, Peritonitis, Antioxidant, Antimicrobial, E. coli

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