Title: A PROSPECTIVE STUDY ON DRUG USE EVALUATION OF THIRD GENERATION CEPHALOSPORINS IN A TERTIARY CARE TEACHING HOSPITAL
Author(s): Prakash Goudanavar, Lovely Panavila, Nijimol Ninan and Pratima K.C
Drug utilization research is an essential part of pharmacoepidemiology as it describes the extent, nature and determinants of drug exposure. The principal aim of drug utilization research is to facilitate the rational use of drugs in populations. Several studies revealed that antibiotics are very often inappropriately used. Appropriate use of antibiotics is central to limiting the development and the spread of resistant bacteria in hospitals and communities. Prospective evaluation of appropriateness of third generation cephalosporins was carried out in 300 in-patients in medicine, surgery, paediatric and orthopaedics wards of Navodaya Medical College Hospital and Research Center, Raichur from November 2015 to April 2016. Drug Utilization evaluation (DUE) was based on standards set forth by the American Society of Hospital Pharmacists. The DUE criteria used in this study were modified to be more suitable in our hospital setting. Relevant information was recorded in a structured proforma& data was evaluated. Ceftriaxone was most frequently prescribed (57.66%) third generation cephalosporins in parenteral form, followed by cefoperazone (16%). Among the 300 patients, 145(48.33%) were female and 155(51.66%) male. With regard to age, 14.66% of males were in 0-10 year’s age group while 7.33% of females were in above 60 years age group. Out of 173 cases of ceftriaxone, the use was appropriate in 115 cases and inappropriate in 58 cases. Out of 48 cases of cefoperazone, the use was appropriate in 39 cases and inappropriate in 9 cases. Our study concludes that the involvement of clinical pharmacists in clinical practice helps to increase proper usage of cephalosporins and optimum outcome.
Keywords: ASHP criteria for DUE, antibiotics, drug utilization evaluation, prescribing pattern.