Title: ANTI-TUBERCULAR ACTIVITY OF DIFFERENT ORGANIC EXTRACTS OF LEAVES OF CAPPARIS DIVARICATA LAM
Author(s): R.V.Hirave, M.S.Kondawar, R.D.Bendgude, T.T.Shelke and S.B.Patil
Tuberculosis is a highly infectious disease with about one third of the world’s population estimated to be infected by it. Plants contain numerous biological active compounds, many of which have been shown to have antimicrobial activity. The search for biologically active extracts based on traditional use of plants is relevant due to the appearance of microbial resistance to many antibiotics and the occurrence of fatal opportunistic infections. The present study was carried out to study antitubercular activity of Capparis divaricata Lam leaves. The anti-mycobacterial activity of compounds were assessed against M. tuberculosis using microplate Alamar Blue assay (MABA).The leaves extracts of Petroleum ether, Chloroform, Ethyl acetate, Acetone, Ethanol, Water was used and prepared different concentrations 100 to 0.2µg/ml. The maximum sensitive extract at 12.5µg/ml was shown by the ethanol extract and aqueous extract as compared to other extract and standard drug used Isoniazid.
KEYWORDS: Capparis Divaricata Lam, Anti-tubercular activity, M. tuberculosis ATTC 27294, Alamar Blue assay.